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ASO vs RNAi / siRNA — Neurology Deal Terms Comparison

ASO Median Upfront
$389M
Total: $3.5B
RNAi / siRNA Median Upfront
$395M
Total: $3.5B
ASO Royalties
12.9%-20.6%
Tiered to 24.6%
RNAi / siRNA Royalties
12.9%-20.6%
Tiered to 24.6%

Market Analysis

In neurology, ASO and RNAi / siRNA represent two of the most actively transacted modalities. At Phase 2, ASO deals carry a median total deal value of $3.5B with $389M upfront, compared to $3.5B total value and $395M upfront for RNAi / siRNA. The valuation difference reflects distinct risk-reward profiles, manufacturing complexity, and competitive dynamics.

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Frequently Asked Questions

How do ASO and RNAi / siRNA deal terms compare in neurology?
ASO Phase 2 deals average $3.5B total deal value ($389M upfront), while RNAi / siRNA deals average $3.5B ($395M upfront). The difference reflects modality-specific risk profiles, manufacturing considerations, and competitive positioning.
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