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Small Molecule vs Psychedelic — Neurology Deal Terms Comparison

Small Molecule Median Upfront
$343M
Total: $3.0B
Psychedelic Median Upfront
$378M
Total: $3.3B
Small Molecule Royalties
12.4%-19.8%
Tiered to 23.8%
Psychedelic Royalties
12.7%-20.3%
Tiered to 24.3%

Market Analysis

In neurology, Small Molecule and Psychedelic represent two of the most actively transacted modalities. At Phase 2, Small Molecule deals carry a median total deal value of $3.0B with $343M upfront, compared to $3.3B total value and $378M upfront for Psychedelic. The valuation difference reflects distinct risk-reward profiles, manufacturing complexity, and competitive dynamics.

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Frequently Asked Questions

How do Small Molecule and Psychedelic deal terms compare in neurology?
Small Molecule Phase 2 deals average $3.0B total deal value ($343M upfront), while Psychedelic deals average $3.3B ($378M upfront). The difference reflects modality-specific risk profiles, manufacturing considerations, and competitive positioning.
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