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RNAi / siRNA vs ASO — Oncology Deal Terms Comparison

RNAi / siRNA Median Upfront
$297M
Total: $1.9B
ASO Median Upfront
$297M
Total: $1.9B
RNAi / siRNA Royalties
12.3%-20.1%
Tiered to 24.1%
ASO Royalties
12.3%-20.1%
Tiered to 24.1%

Market Analysis

In oncology, RNAi / siRNA and ASO represent two of the most actively transacted modalities. At Phase 2, RNAi / siRNA deals carry a median total deal value of $1.9B with $297M upfront, compared to $1.9B total value and $297M upfront for ASO. The valuation difference reflects distinct risk-reward profiles, manufacturing complexity, and competitive dynamics.

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Frequently Asked Questions

How do RNAi / siRNA and ASO deal terms compare in oncology?
RNAi / siRNA Phase 2 deals average $1.9B total deal value ($297M upfront), while ASO deals average $1.9B ($297M upfront). The difference reflects modality-specific risk profiles, manufacturing considerations, and competitive positioning.
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