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Phenylketonuria (PKU) — Deal Benchmarks & Valuation

Median Upfront
$239M
Range: $111M - $367M
Total Deal Value
$1.9B
Range: $1.0B - $2.7B
Royalty Rate
9.4% - 17.6%
Tiered up to 21.6%
Dev Milestones
$493M
Range: $278M - $709M

Market Analysis

Phenylketonuria (PKU) is one of the most actively transacted indications in metabolic licensing. Phase 1 deals for phenylketonuria (pku) carry a median total deal value of $1.9B, with upfront payments ranging from $111M to $367M. The recommended deal structure allocates approximately 13% to upfront payments and 87% to milestones.

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Frequently Asked Questions

What are typical deal terms for phenylketonuria (pku) licensing?
Phase 1 phenylketonuria (pku) licensing deals average $239M in upfront payments with $1.9B total deal value. The 13/87 upfront/milestone split reflects the risk profile at this clinical stage.
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