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Rare Disease vs Cardiovascular — Deal Terms Comparison

Rare Disease Median Upfront
$285M
Total: $1.6B
Cardiovascular Median Upfront
$606M
Total: $3.0B
Rare Disease Royalties
7.8%-15.6%
Tiered to 19.6%
Cardiovascular Royalties
9.4%-18.7%
Tiered to 22.7%

Market Analysis

Rare Disease and Cardiovascular represent distinct licensing landscapes with different risk-reward dynamics. Phase 2 rare disease deals carry a median total deal value of $1.6B with $285M upfront, compared to $3.0B total value and $606M upfront for cardiovascular. The differences reflect divergent clinical development timelines, regulatory pathways, and addressable market sizes.

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Frequently Asked Questions

How do rare disease and cardiovascular deal terms compare?
Rare Disease Phase 2 deals average $1.6B total value ($285M upfront), while Cardiovascular deals average $3.0B ($606M upfront). The differences are driven by addressable market size, clinical development complexity, and regulatory pathway characteristics.
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