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Neurology/CNS Preclinical Deal Benchmarks — Ex-US (2026)

Median upfront of $15M with total deal values reaching $533M in Ex-US territory.

Median Upfront

$15M

Total Deal Value

$323M

Royalty Range

3.4%–6.8%

Territory Multiplier

0.45x

Understanding Neurology/CNS Deal Benchmarks at Preclinical

Preclinical Neurology/CNS licensing deals in Ex-US territory command a median upfront payment of $15M, with values ranging from $4M at the low end to $27M for premium assets. These benchmarks reflect the risk-adjusted value of clinical-stage assets in the neurology/cns therapeutic area, where development costs, competitive dynamics, and market potential all factor into deal pricing.

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Full Benchmark Data

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Low, median, and high ranges for upfront payments, total deal values, and royalty rates.

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Comparable Deals

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View 1 comparable Neurology/CNS transactions with upfront payments, total values, and deal structures.

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Frequently Asked Questions

What is the average upfront payment for Preclinical Neurology/CNS deals in Ex-US territory?
The median upfront payment for Preclinical Neurology/CNS licensing deals in Ex-US territory is $15M, based on our analysis of comparable transactions. Values range from $4M for early-stage or less differentiated assets up to $27M for premium programs with strong clinical data or first-in-class mechanisms.
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Cite This Data

APA

Ambrosia Ventures. (2026). Neurology/CNS Preclinical Deal Benchmarks — Ex-US (2026). Retrieved from https://calculator.ambrosiaventures.co/data/neurology-preclinical-deals-ex-us

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<a href="https://calculator.ambrosiaventures.co/data/neurology-preclinical-deals-ex-us">Neurology/CNS Preclinical Deal Benchmarks — Ex-US (2026)</a> — Ambrosia Ventures (2026)

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Data sourced from 1,900+ verified biopharma transactions. Updated monthly.