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Heart Failure (HFrEF) — Deal Benchmarks & Valuation

Median Upfront
$606M
Range: $330M - $874M
Total Deal Value
$3.0B
Range: $2.0B - $4.1B
Royalty Rate
9.4% - 18.7%
Tiered up to 22.7%
Dev Milestones
$537M
Range: $363M - $713M

Market Analysis

Heart Failure (HFrEF) is one of the most actively transacted indications in cardiovascular licensing. Phase 2 deals for heart failure (hfref) carry a median total deal value of $3.0B, with upfront payments ranging from $330M to $874M. The recommended deal structure allocates approximately 20% to upfront payments and 80% to milestones.

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Frequently Asked Questions

What are typical deal terms for heart failure (hfref) licensing?
Phase 2 heart failure (hfref) licensing deals average $606M in upfront payments with $3.0B total deal value. The 20/80 upfront/milestone split reflects the risk profile at this clinical stage.
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