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In Vivo CAR-T vs CAR-T (Autoimmune) — Immunology Deal Terms Comparison

In Vivo CAR-T Median Upfront
$652M
Total: $3.5B
CAR-T (Autoimmune) Median Upfront
$914M
Total: $5.0B
In Vivo CAR-T Royalties
14.6%-24.3%
Tiered to 28.3%
CAR-T (Autoimmune) Royalties
16.3%-27.2%
Tiered to 31.2%

Market Analysis

In immunology, In Vivo CAR-T and CAR-T (Autoimmune) represent two of the most actively transacted modalities. At Phase 2, In Vivo CAR-T deals carry a median total deal value of $3.5B with $652M upfront, compared to $5.0B total value and $914M upfront for CAR-T (Autoimmune). The valuation difference reflects distinct risk-reward profiles, manufacturing complexity, and competitive dynamics.

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Frequently Asked Questions

How do In Vivo CAR-T and CAR-T (Autoimmune) deal terms compare in immunology?
In Vivo CAR-T Phase 2 deals average $3.5B total deal value ($652M upfront), while CAR-T (Autoimmune) deals average $5.0B ($914M upfront). The difference reflects modality-specific risk profiles, manufacturing considerations, and competitive positioning.
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Complete deal term ranges, comparable transactions, and negotiation insights.

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