Cardiovascular Phase 2 Deal Benchmarks — US Only (2026)

Median upfront of $278M with total deal values reaching $1.9B in US Only territory.

Median Upfront

$278M

Total Deal Value

$1.4B

Royalty Range

7.4%–14.7%

Territory Multiplier

0.55x

Understanding Cardiovascular Deal Benchmarks at Phase 2

Phase 2 Cardiovascular licensing deals in US Only territory command a median upfront payment of $278M, with values ranging from $153M at the low end to $398M for premium assets. These benchmarks reflect the risk-adjusted value of clinical-stage assets in the cardiovascular therapeutic area, where development costs, competitive dynamics, and market potential all factor into deal pricing.

Total deal values — including milestones for development, regulatory, and commercial achievements — range from $892M to $1.9B, with a median of $1.4B. Royalty rates for cardiovascular assets at this stage typically fall between 7.4% and 14.7% of net sales, reflecting the balance between licensor value contribution and licensee commercialization investment.

The US Only territory applies a 0.55x multiplier to base deal economics. This accounts for market size, regulatory complexity, pricing environment, and competitive landscape differences across geographies. Licensors negotiating us only rights should calibrate upfront expectations and milestone structures accordingly.

PRO

Full Market Analysis

Detailed deal economics, territory impact analysis, and royalty structure breakdown.

We'll email you the full benchmark data for this page. No spam, unsubscribe anytime.

Unlock Everything — $299/mo Pro

7-day money-back guarantee · Cancel anytime

Full Benchmark Data

PRO

Full Benchmark Table

Low, median, and high ranges for upfront payments, total deal values, and royalty rates.

We'll email you the full benchmark data for this page. No spam, unsubscribe anytime.

Unlock Everything — $299/mo Pro

7-day money-back guarantee · Cancel anytime

Comparable Deals

PRO

See All Comparable Deals

View 0 comparable Cardiovascular transactions with upfront payments, total values, and deal structures.

We'll email you the full benchmark data for this page. No spam, unsubscribe anytime.

Unlock Everything — $299/mo Pro

7-day money-back guarantee · Cancel anytime

Frequently Asked Questions

What is the average upfront payment for Phase 2 Cardiovascular deals in US Only territory?

The median upfront payment for Phase 2 Cardiovascular licensing deals in US Only territory is $278M, based on our analysis of comparable transactions. Values range from $153M for early-stage or less differentiated assets up to $398M for premium programs with strong clinical data or first-in-class mechanisms.

How does US Only territory affect Cardiovascular deal value?

US Only rights carry a 0.55x multiplier relative to base deal economics. This means us only cardiovascular deals are valued at a discount compared to single-country rights, reflecting the combined market opportunity, regulatory pathway, and competitive dynamics of the territory.

What royalty rates are typical for Phase 2 Cardiovascular licensing?

Royalty rates for Phase 2 cardiovascular assets typically range from 7.4% to 14.7% of net sales. The exact rate depends on the licensor's contribution (IP, clinical data, manufacturing), deal structure (exclusive vs. co-exclusive), and the licensee's commercialization investment. Higher royalties often correspond to lower upfront payments, and vice versa.

PRO

More Expert Insights

Territory impact analysis, royalty negotiation strategies, and deal structure guidance.

We'll email you the full benchmark data for this page. No spam, unsubscribe anytime.

Unlock Everything — $299/mo Pro

7-day money-back guarantee · Cancel anytime

Related Benchmarks

$28M upfront

Cardiovascular · Preclinical · US Only

$72M upfront

Cardiovascular · Phase 1 · US Only

$759M upfront

Cardiovascular · Phase 3 · US Only

$2.1B upfront

Cardiovascular · Approved · US Only

$142M upfront

Oncology · Phase 2 · US Only

$128M upfront

Neurology/CNS · Phase 2 · US Only

$301M upfront

Immunology · Phase 2 · US Only

$324M upfront

Metabolic/Obesity · Phase 2 · US Only

Explore More

All Cardiovascular Deals

View full therapeutic area benchmarks

Licensing Benchmarks Guide

2026 data from 1,900+ deals

Royalty Rate Benchmarks

Negotiation strategies by phase & modality

Run Custom Analysis

Pre-filled with Cardiovascular · Phase 2

Run Your Own Benchmark

These benchmarks are starting points. Get a customized valuation for your specific asset, indication, and deal structure.

Open Deal Calculator

Cite This Data

APA

Ambrosia Ventures. (2026). Cardiovascular Phase 2 Deal Benchmarks — US Only (2026). Retrieved from https://calculator.ambrosiaventures.co/data/cardiovascular-phase-2-deals-us

HTML

<a href="https://calculator.ambrosiaventures.co/data/cardiovascular-phase-2-deals-us">Cardiovascular Phase 2 Deal Benchmarks — US Only (2026)</a> — Ambrosia Ventures (2026)

Embed Chart

Data sourced from 1,900+ verified biopharma transactions. Updated monthly.

Metric	Low	Median	High
Upfront Payment	$153M	$278M	$398M
Total Deal Value	$892M	$1.4B	$1.9B
Royalty Rate	7.4%	—	14.7%