Cardiovascular Phase 2 Deal Benchmarks — US Only

Understanding Cardiovascular Deal Benchmarks at Phase 2

Phase 2 Cardiovascular licensing deals in US Only territory command a median upfront payment of $278M, with values ranging from $153M at the low end to $438M for premium assets. These benchmarks reflect the risk-adjusted value of clinical-stage assets in the cardiovascular therapeutic area, where development costs, competitive dynamics, and market potential all factor into deal pricing.

Total deal values — including milestones for development, regulatory, and commercial achievements — range from $892M to $1.9B, with a median of $1.4B. Royalty rates for cardiovascular assets at this stage typically fall between 7.4% and 14.7% of net sales, reflecting the balance between licensor value contribution and licensee commercialization investment.

The US Only territory applies a 0.55x multiplier to base deal economics. This accounts for market size, regulatory complexity, pricing environment, and competitive landscape differences across geographies. Licensors negotiating us only rights should calibrate upfront expectations and milestone structures accordingly.