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Spinal Muscular Atrophy (SMA) — Deal Benchmarks & Valuation

Median Upfront
$363M
Range: $176M - $553M
Total Deal Value
$2.0B
Range: $1.2B - $2.8B
Royalty Rate
8.4% - 16.8%
Tiered up to 20.8%
Dev Milestones
$361M
Range: $217M - $505M

Market Analysis

Spinal Muscular Atrophy (SMA) is one of the most actively transacted indications in rare disease licensing. Phase 2 deals for spinal muscular atrophy (sma) carry a median total deal value of $2.0B, with upfront payments ranging from $176M to $553M. The recommended deal structure allocates approximately 18% to upfront payments and 82% to milestones.

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Frequently Asked Questions

What are typical deal terms for spinal muscular atrophy (sma) licensing?
Phase 2 spinal muscular atrophy (sma) licensing deals average $363M in upfront payments with $2.0B total deal value. The 18/82 upfront/milestone split reflects the risk profile at this clinical stage.
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